Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет
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Тип записи:Публикация, СИНТЕЗ НОВЫХ α-АМИНОФОСФОНАТОВ НА ОСНОВЕ ЦИКЛОГЕКСИЛАМИНОВ В УСЛОВИЯХ РЕАКЦИИ КАБАЧНИКА-ФИЛДСА(2021-04-17); ; ; Alexander Romanovich BurilovNew α-aminophosphonates were synthesized and characterized by the interaction of cyclohexylamine and 1-ethynyl-1-amino-cyclohexane with various benzaldehydes and diethyl phosphite under the conditions of the Kabachnik-Filds reaction. The composition and structure of the synthesized compounds were confirmed by IR, NMR 1 H and 31P spectroscopy References [1] Cherkasov R.A., Galkin V.I. Reakcija Kabachnika-Fildsa: Sinteticheskij potencial i problem mehanizma // Usp. himii. 1998. Vol. 67, vyp. 10. P. 940-968. [2] Kosyhova L.A., Pikshilingajte Ju.-V.K., Zaks A.S., Rabotnikov Ju.M. Sintezi protivo vospalitel'naja aktivnost' diamidofosforil'nyh proizvodnyh aminociklogeksana // Him-farm. zh. 1996. No. 5. P. 45-46. [3] Dzhiembaev B.Zh. α-оksi- α-aminofosfonatyshestichlennyh (N, O, S, Se) geterociklov. Almaty: Kompleks, 2003. 234 p. [4] Cherkasov R.A., Galkin V.I, Galkina I.V., Garifzjanov A.R., Sobanov A.A. Aminofosfo-naty: mehanizmy obrazovanija, reakcionnaja sposobnost' i analiticheskie svojstva // Butlerovskie soobshhenija. 2005. Vol. 6. P. 30-36. [5] Glushkov V.A., P'yankova O.S., Anikina L.V., Vikharev Yu.B., Feshina Ye.V., Shklyayev Yu.V., Tolstikov A.G. Sintez i neyrotropnaya aktivnost' proizvodnykh tsiklogeksilamina // Khim.-farm. registr. 2006. Vol. 40, No. 6. P. 80-84. [6] Pawel Kafarski, Micha Gornyvel Gorniak and Iga Andrasiak Kabachnik-Fields Reaction Under Green Conditions – A Critical Overview // Current Green Chemistry. 2015. 2. P. 218-222. [7] Mucha A., Kafarski P., Berlicki Ł. Remarkable Potential of ther-Aminophosphona-te/Phosphinate Structural Motif in Medicinal Chemistry J. Med. Chem. 2011. 54. 5955. [8] Adam Tajti, Erika Balint, Gyorgy Keglevich Micro wave-assisted synthesis of α-amino-phosphonates and related derivatives by the Kabachnik-Fields reaction // Phosphorus, Sulfur, and Silicon and the Related Elements. 2019. 194:4-6. P. 379-381. [9] Romanowska J., Kolodziej K., Sobkowski M., Rachwalak M., Jakubowski T., Golebiewska J., Kraszewski A., Boryski J., Dabrowska A., Stawinski J. Aryl H-phosphonates. 19. New anti-HIV pronucleotidephosphoramidatediesters containing amino- and hydroxypyridineauxiliaries // Eur. J. Med. Chem. 2019. 164. 47. [10] Romero-Estudillo I., Viveros-Ceballos J.L., Cazares-Carreno O., Gonzalez-Morales A., de Jesus B.F., Lopez-Castillo M., Razo-Hernandez R.S., Castaneda-Corral G., Ordonez M. 000Synthesis of new α-aminophosphonates: Evaluation as antiinflammatory agents and QSAR studies Bioorg. Med. Chem. 2019. 27. 2376. [11] Smolobochkin A.V., Gazizov, A.S. Doszhanova K.A., Dzhiyembayev B.Zh., Kuandyko-va A.B., Burilov A.R., Pudovik M.A Sintez novykh a-aminofosfonatov na osnove tsiklogeksilamina // Zhurnal organicheskoy khimii. 2020. Vol. 90, No. 6. P. 980-984. [12] Kuandykova A.B., Doszhanova K.A., Myrzakhmetova N.O., Kishibayev K.O. Sintez novykh a-aminofosfonatov v usloviyakh reaktsii Pudovika // Khimicheskiy zhurnal Kazakhstana. 2020. No. 1(69). P. 198-204. - Некоторые метрики заблокированы вашиминастройками согласия
Тип записи:Публикация, Isolation and Biotesting of Tannins from Eichhornia crassipes plants: Pom analyses and Antifungal/antiviral Pharmacophore sites Identification(2025-04-12); ; Madina AmangeldinovaNutrients produce various secondary metabolites, including biologically active compounds such as antifungals. The composition of E. Crassipes aquatic plant contains biologically active substances. In this article, the composition of substances in E. Crassipes was identified using IR, 1H, and 13C-NMR methods. The identified substances were characterized for biological activity using the PASS online program. This was based on their molecular structure. As a result of the program, compounds showing activity against light, viruses, earwigs, and bacteria were developed. The program's scope included testing the substances' antimicrobial activity using agar diffusion assay in experiments. Substances were extracted from the aquatic plant via chromatography-mass spectrometry, and their activity against earwigs was examined. The study revealed efficacy against Candida albicans and Candida utilis earwigs. - Некоторые метрики заблокированы вашиминастройками согласия
Тип записи:Публикация, Iodine-Based Coordination Compounds: A Strategy Toward Antibiotic Potentiation(Multidisciplinary Digital Publishing Institute, 2026-05-12); Ardak B. JumagaziyevaDue to the increasing threat of antibiotic resistance and the emergence of new pathogenic strains, the development of effective combined therapeutic agents represents a crucial direction in the fight against infections. Within this study, several compounds were synthesized in which iodine is present in a coordination complex with antibiotics—sodium sulfadimidine and gentamicin sulfate. The physicochemical parameters of these compounds were investigated using capillary electrophoresis and UV spectroscopy, along with their cytotoxicity, antimicrobial, and antiviral activities. As a result of this work, two stable compounds, KC-246 and KC-248, were synthesized, demonstrating virus-inhibitory activity against herpes simplex virus and influenza A under extremely low cytotoxicity levels of 0.018–0.106 mg/mL. Additionally, they exhibited antimicrobial activity against representatives of the families Staphylococcaceae, Pseudomonadaceae, Enterobacteriaceae, Enterococcaceae, and yeast-like fungi. The minimum bactericidal concentrations (MBCs) ranged from 0.794 µg/mL to 0.198 µg/mL (KC-246) and from 2.093 µg/mL to 0.523 µg/mL (KC-248).Цитирования (OpenAlex) 2