Жарияланымдар / Публикации

Постоянный URI для этого сообществаhttps://cris.qyzpu.edu.kz/handle/123456789/2

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Дата начала: 2024Тема: search.filters.subject.flavonoids

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    Тип записи:Публикация,
    STUDY OF TANNING SUBSTANCES AND FLAVANOIDS IN THE LEAVES OF ASIAN AGRIMONY(AGRIMONIA ASIATICA JUZ.)
    (Al-Farabi Kazakh National University, 2024-01-01)
    Anar Nurgaiypovna Kaliyeva
    ;
    Nurgul Mamytova
    ;
    Г. Ж. Медеуова
    ;
    Damezhan Sadykova
    ;
    Zaida Rakhimova
    Asian agrimony (Agrimonia asiatica Juz) is a common wild plant including that growing within the territory of Kazakhstan, a very promising raw material for flavonoids and tanning substances release. These active substances have significant pharmacological potential. The article presents the results of work on determining the quantitative and qualitative composition of tannins and flavonoids in plant raw materials from the Asian agrimony (Agrimonia asiatica Juz). The presence of tanning substances and flavonoids in the extracts received from the above-ground part of Asian agrimony has been established by qualitative reactions. Various developers for paper chromatography have been used. The quantita-tive determination of flavonoids has been carried out in terms of the equivalent amount of quercetine, and the standard method of permanganatometric titration has been used to determine the quantitative content of tanning substances. Quantitative content of tanning substances in the leaves of Asian agri-mony (A. asiatica juz.) showed an 8,156 %, and a quantitative content of flavonoids showed 1,9 %. The purpose of the study is to determine the quantitative and qualitative composition of tannins and flavanoids in prepared herbal medicinal raw materials in order to identify the most promising objects for further research.
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    Adaptation Features of Gentiana tianschanica Rupr. Populations to Environmental Factors in Kazakhstan
    (2024-01-01)
    Бекзат Тыныбеков
    ;
    Moldir Imanaliyeva
    ;
    Askhat Kuatbayev
    ;
    Gulmira Satybaldiyeva
    ;
    Elmira Boribay
    The study investigates the current state, floristic composition, and ecological characteristics of Gentiana tianschanica populations in the Ile-Alatau region, part of the Ile-Alatau National Park, Kazakhstan.Gentiana L., an ancient boreal genus, includes 31 species in Kazakhstan, such as the endemic Gentiana dschungarica.Known for medicinal uses, especially for gastrointestinal and urogenital disorders, interest in gentians has risen for ornamental and pharmacological applications.Nine natural populations of G. tianschanica were studied in diverse ecological and phytocoenotic conditions of the Ile-Alatau mountains.Soil analyses revealed significant differences in the physicochemical properties of the species' habitats.In the Kimasar Gorge, mountain-meadow chestnut soils with a light loamy texture were observed, while the Big Almaty Gorge featured dark chestnut soils rich in humus (7.36-18.78%)and nutrients such as nitrogen (120.4-140.0mg/kg), phosphorus (58-98 mg/kg), and potassium (470-1000 mg/kg).These findings emphasize the species 'adaptation to varying altitudinal and climatic zones.Phytochemical analysis showed G. tianschanica is rich in bioactive compounds, including phenolics, bitter glycosides, flavonoids, and alkaloids.Total phenol content reached 1567.17-9008.20mg of gallic acid/100 g, with the highest levels in leaves.Flavonoids (up to 1358.25 mg catechin/100 g) and vitamin C (up to 244.7 mg/100 g) were significant.Syringic acid (1685.8mg/100 g), quercetin (317.4 mg/100 g), and chlorogenic acid (237.5 mg/100 g) highlighted antioxidant and antiinflammatory potential.The antioxidant activity, particularly in leaves, reached 530.30 mg Trolox/100 g.Anthropogenic threats, including overgrazing and habitat disturbance, have led to declining populations, necessitating conservation strategies like habitat monitoring, protective regimes, and sustainable medicinal plant use.This study underscores the ecological and phytochemical significance of G. tianschanica, which is vital for biodiversity conservation and pharmaceutical development.
    Цитирования (OpenAlex) 2Цитирования (OpenCitations) 3
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    Phytochemical composition and antioxidant, antimicrobial, and cytotoxic activities of different solvent extracts of Ajania fastigiata (C. Winkl.) Poljakov
    (Instituto Internacional de Ecologia (Brazil), 2025-01-01)
    Assem Mamurova
    ;
    G. Kairanova
    ;
    G.A. Amеrtayeva
    ;
    Aigul Yedilova
    ;
    Asylkhan A. Rakhymzhan
    This study investigates the phytochemical composition and biological activities of six solvent extracts-hexane, ethyl acetate, and hydroethanolic fractions-from the roots and aerial parts of Ajania fastigiata (C. Winkl.) Poljakov (Asteraceae), collected in the mountain regions of southeastern Kazakhstan. Phytochemical analysis revealed that the aerial ethyl acetate extract contained the highest levels of bioactive metabolites, including phenolic compounds (34.22 ± 1.98 mg GAE/g), flavonoids (2.74%), organic acids (1.91%), and coumarins (0.54%). Antioxidant potential was evaluated using DPPH and ABTS radical-scavenging assays, with values of SC50 = 133.98 ± 12.91 µg/mL (DPPH) and 209.21 ± 3.70 mg Trolox/g (ABTS). The minimum inhibitory concentration (MIC), determined by the broth microdilution method, showed strong antimicrobial activity of the aerial ethyl acetate fraction, particularly against P.aeruginosa (MIC = 9 µg/mL) and E.faecalis (MIC = 39 µg/mL). Cytotoxicity was assessed by the MTT assay on NIH-3T3, K562, and Saos cell lines. The aerial ethyl acetate fraction exhibited selective cytotoxic effects, with IC50 values of 210 µg/mL for K562 and 360 µg/mL for Saos, while showing negligible activity toward normal fibroblasts (IC50 > 2500 µg/mL). These results confirm the pharmacological potential of A.fastigiata as a promising natural source of antioxidant, antimicrobial, and anticancer agents.
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    Nutritive and Prebiotic Potentials of Chlorella and Scenedesmus Microalgae
    (2026-01-01)
    Gulzira Izmukhanovna Yernazarova
    ;
    С. К. Кабдрахманова
    ;
    Svetlana Kazbekovna Turasheva
    ;
    А.А. Ramazanova
    ;
    Khaiyrnisa Aisakulova
    We investigated the prebiotic properties of Chlorella sp. and Scenedesmus sp.microalgae based on the analysis of their extracts.We used High-performance liquid chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR) for chemical characterisation of extract composition.Using HPLC at 272 nm, the flavonoid naringenin was identified in the extract at a concentration of 1.343
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    Comparative phytochemical and GC-MS analysis of leaves, stems, and roots of Euphorbia yaroslavii Poljakov.
    (Instituto Internacional de Ecologia (Brazil), 2026-01-01)
    Abibulla Ametov
    ;
    Marzhankul Dauletbayeva
    ;
    М.О. Айтжанова
    ;
    Zaida Rakhimova
    ;
    Sarsembayeva Aiman
    Euphorbia yaroslavii Poljakov. is a rare plant species endemic to Kazakhstan whose phytochemical composition has remained largely unexplored. This study presents the first organ-specific phytochemical and GC-MS characterization of the leaves, stems, and roots of this species. Quantitative analyses indicated pronounced metabolic differentiation among plant organs. Roots were characterized by high contents of total phenolics (58.2 ± 2.5 mg GAE/g DW), coumarins (2.48%), and mineral components (total ash 13.22%), while leaves exhibited the highest tannin content (2.35%). The maximum flavonoid content was observed in roots (0.27%), whereas stems contained the highest level of ascorbic acid (0.70 mg/g DW). GC-MS profiling tentatively identified 68 compounds in leaf extracts, 65 in stem extracts, and 39 in root extracts. Root extracts were dominated by fatty acids and triterpenoid-sterol constituents, including octadecanoic acid (18.9%), hexadecanoic acid (17.5%), β-amyrin (5.2%), and lanosterol (4.9%). Overall, the results indicate organ-specific metabolic specialization in Euphorbia yaroslavii Poljakov. and provide a reliable phytochemical baseline for future bioactivity-oriented and conservation-related studies.
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    ГЕНОМНАЯ ОЦЕНКА ГЕНЕТИЧЕСКОГО РАЗНООБРАЗИЯ ПОПУЛЯЦИЙ CALLIGONUM LEUCOCLADUM (SCHRENK) BUNGE ЛЕКАРСТВЕННОГО В ПУСТЫНЕ КЫЗЫЛКУМ C. LEUCOCLADUM
    (Astana International University, 2026-03-27)
    М.Е. Мусина
    ;
    Bekzat Tynybekov
    ;
    А.С. Нурмаханова
    ;
    Elmira Imаnova
    ;
    H. Morgıl
    Calligonum leucocladum (Schrenk) Bunge - экологически важный пустынный кустарник, адаптированный к засушливым и полузасушливым условиям Центральной Азии. Эта работа впервые предлагает комплексную оценку генетического разнообразия, структуры популяции и фитохимической изменчивости вида с использованием генотипа SNP с высоким разрешением и хемометрического профиля. Было проанализировано 150 особей из трех географически разделенных популяций (P1, P2 и P3) пустыни Кызылкум и прилегающих регионов. Анализ распада связывающего равновесия (LD) показал, что популяция P3 характеризуется самым высоким уровнем рекомбинации (r2 резко падает на 10 кб), в то время как P2 демонстрирует сильную LD на больших расстояниях, что указывает на среднюю генетическую изоляцию. Базовый координатный анализ (PCoA) объяснил 76,55% общей генетической изменчивости и подтвердил фактическую дифференциацию P1, в то время как P2 и P3 показали генетическое родство. Анализ минимального связующего дерева (MST) дополнительно подтвердил эти закономерности. Фитохимический профиль впервые выявил популяционные различия в общих фенолах, флавоноидах и антиоксидантных способностях, которые соответствуют генетической структуре. Результаты показывают, что географическая изоляция, фрагментация среды обитания и экологический стресс способствуют расхождению популяций. Высокое генетическое и биохимическое разнообразие популяции P3 определяет ее как потенциальный резервуар адаптивных признаков. Эта работа является ценной основой для планирования природоохранных мероприятий и экологического восстановления пустынной флоры.
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    Phytochemical Profiling and Toxicological Evaluation of Atraphaxis virgata and Atraphaxis pyrifolia Extracts Using GC–MS and LC–MS
    (Multidisciplinary Digital Publishing Institute, 2026-05-23)
    Meruyert D. Dauletova
    ;
    Almagul K. Umbetova
    ;
    Aisulu Zh. Kabdraisova
    ;
    Ryzvangul S. Ymynova
    ;
    G. Sh. Burasheva
    Atraphaxis virgata and Atraphaxis pyrifolia are xerophytic species of the Polygonaceae family that remain insufficiently characterized from pharmacognostic, phytochemical, and toxicological perspectives. This study provides an integrated evaluation of both species through anatomical authentication, sequential extraction of CO2-extracted residual biomass, GC–MS and LC–MS metabolite profiling, and acute oral toxicity assessment. Anatomical analysis revealed shared xeromorphic traits, including cuticular protection, dorsiventral mesophyll organization, structured vascular bundles, and calcium oxalate druses. It also identified species-specific differences in leaf thickness, mesophyll arrangement, vascular architecture, and druse morphology. GC–MS analysis showed distinct chemical profiles: A. virgata displayed a concentrated profile dominated by acetophenone- and benzofuran-related constituents, whereas A. pyrifolia showed a broader spectrum of carbohydrate-derived, phenolic-related, and oxygenated constituents. LC–MS analysis supported the tentative annotation of diverse polyphenolic classes, including flavonoids, phenolic acids, coumarins, and phenylpropanoid derivatives. Acute oral toxicity testing showed no mortality at doses up to 2000 mg/kg, supporting a low acute oral toxicity classification under the tested conditions. However, histological examination revealed mild to moderate dose-dependent alterations in liver and kidney tissues at higher doses. The novelty of this work lies in linking diagnostic anatomical traits, species-specific metabolite patterns, residual biomass valorization, and preliminary safety evidence within a single comparative framework. These findings provide a basis for pharmacognostic authentication, phytochemical standardization, and future bioactivity-guided evaluation of Atraphaxis species.